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22 | 10 | 2017
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Study

Burnout impacts transplant nurses

 

  • More than half are emotionally exhausted, feel low personal accomplishment

 

DETROIT, MI, USA (October 6, 2015) - More than half of nurses who work with organ transplant patients in the United States experience high levels of emotional exhaustion, a primary sign of burnout, according to a study published by researchers at Henry Ford Hospital. In addition, 52% of the nurses surveyed reported feeling low levels of personal accomplishment in their life-saving work, according to findings published recently in Progress in Transplantation, a journal of the American Association of Critical-Care Nurses.

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American placebo

 

  • New analysis of chronic pain drug trials shows increasing placebo responses over time, in the US only

 

MONTREAL, Canada (Oct. 6, 2015) - A new study finds that rising placebo responses may play a part in the increasingly high failure rate for clinical trials of drugs designed to control chronic pain caused by nerve damage. Surprisingly, however, the analysis of clinical trials conducted since 1990 found that the increase in placebo responses occurred only in trials conducted wholly in the U.S.; trials conducted in Europe or Asia showed no changes in placebo responses over that period.

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Rutgers research provides clues to keeping brain cells alive in those with Alzheimer's

Drug used to treat cancer appears to sharpen memory

 

New Brunswick, NJ, USA (October 2, 2015) - Can you imagine a drug that would make it easier to learn a language, sharpen your memory and help those with dementia and Alzheimer's disease by rewiring the brain and keeping neurons alive? New Rutgers research published in the Journal of Neuroscience found that a drug - RGFP966 - administered to rats made them more attuned to what they were hearing, able to retain and remember more information, and develop new connections that allowed these memories to be transmitted between brain cells.

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Results highlight adolescent bedtimes as a potential target for weight Management

Later bedtimes may lead to an increase in body mass index over time

 

DARIEN, IL, USA (October 1, 2015) - A new study suggests that going to bed late during the workweek from adolescence to adulthood is associated with an increase in body mass index over time. Results of hierarchal linear models involving a nationally representative sample of more than 3,000 participants show that going to bed during the workweek each additional hour later is associated with an increase in BMI of 2.1 kg/m2. Moreover, surprising to the researchers, the relationship between bedtime and BMI was not significantly changed or moderated by total sleep time, exercise frequency or screen time.

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Multiple Sclerosis

New study removes cancer doubt for multiple sclerosis drug

 

London, UK (October 1,  2015) - Researchers from Queen Mary University of London (QMUL) are calling on the medical community to reconsider developing a known drug to treat people with relapsing Multiple sclerosis (MS) after new evidence shows it does not increase the risk of cancer as previously thought.

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Large-scale Swedish study discovers link between height and cancer

Link between height and cancer

 

Bristol, UK (October 1, 2015) - Cancer risk has been found to increase with height in both Swedish men and women, according to research presented today at the 54th Annual European Society for Paediatric Endocrinology Meeting. This long-term study is the largest carried out on the association between height and cancer in both genders.

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Nephrology

Tallness linked to increased risk of premature death for patients on dialysis

 

  • Findings are opposite to those seen in the general population

 

Highlights

 

  • In contrast to studies in the general population, tallness was associated with higher premature mortality risk and shorter life spans in patients on dialysis.
  • The association was observed in white, Asian, and American Indian/Alaskan native patients, but not in black patients.
  • The overall paradoxical relationship between height and premature death was not explained by concurrent illness, socioeconomic status, or differences in care.
  • Approximately 2 million patients in the world receive dialysis treatments.

 

Washington, DC, USA (October 1, 2015) -- Although tall people in the general population tend to live longer than shorter people, the opposite appears to be true for patients receiving dialysis. The findings, which are published in a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN), could provide valuable information for kidney specialists.

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Medications to treat opioid use disorders

New guideline from the American Society of Addiction Medicine

 

Chevy Chase, MD, USA (September 24, 2015) - Medications play an important role in managing patients with opioid use disorders, but there are not enough physicians with the knowledge and ability to use these often-complex treatments. New evidence-based recommendations on the use of prescription medications for the treatment of opioid addiction are published in the October/November Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine (ASAM).

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DNA sequencing

Improving the treatment of urinary infections

 

Norwich, Norfolk, UK (September 19, 2015) - Urinary tract infections (UTIs) could be treated more quickly and efficiently using a DNA sequencing device the size of a USB stick - according to research from the University of East Anglia. Researchers used a new device called MinION to perform nanopore sequencing to characterise bacteria from urine samples four times more quickly than using traditional methods of culturing bacteria. The new method can also detect antibiotic resistance - allowing patients to be treated more effectively and improving stewardship of diminishing antibiotic reserves.

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New method could help nurses spot delirium quickly

 

UNIVERSITY PARK, Pa., USA (September 15, 2015) - Asking just two questions may be able to help nurses and doctors quickly and easily identify delirium in hospitalized older adults, according to health researchers. Delirium is a reversible cognitive condition that can be resolved if caught and treated early.

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New pathway toward a vaccine against MRSA ?

 

  • Key finding of dueling bacterial toxins shows why hospital superbug is so deadly -- and its close relatives are not

 

New York, N.Y., USA (September 9, 2015) - New research led by NYU Langone Medical Center has uncovered why a particular strain of Staphylococcus aureus -- known as HA-MRSA -- becomes more deadly than other variations. These new findings open up possible new pathways to vaccine development against this bacterium, which the Centers for Disease Control and Preventions says accounts for over 10,000 deaths annually, mostly among hospital patients.

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Diabetes drug boosts bone fat and fracture risk; exercise can partially offset the effect

 

  • A new UNC School of Medicine study visualizes the dramatic influence of a diabetes drug on bone health and the benefit of exercise in mice.

 

CHAPEL HILL, NC (September 8, 2015) - Inside our bones there is fat. Diabetes increases the amount of this marrow fat. And now a study from the UNC School of Medicine shows how some diabetes drugs substantially increase bone fat and thus the risk of bone fractures. The study, published in the journal Endocrinology, also shows that exercise can decrease the volume of bone fat caused by high doses of the diabetes drug rosiglitazone, which is sold under the brand name Avandia.

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Structural differences found in depressed, non-depressed People

Common antidepressant may change brain

 

WINSTON-SALEM, N.C., USA (September 4, 2015) - A commonly prescribed antidepressant may alter brain structures in depressed and non-depressed individuals in very different ways, according to new research at Wake Forest Baptist Medical Center. The study - conducted in nonhuman primates with brain structures and functions similar to those of humans - found that the antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI) marketed as Zoloft, significantly increased the volume of one brain region in depressed subjects but decreased the volume of two brain areas in non-depressed subjects.

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FDA approves new drug treatment for nausea and vomiting from chemotherapy

 

Silver Spring, MD, USA (September 2, 2015) - The U.S. Food and Drug Administration approved Varubi (rolapitant) to prevent delayed phase chemotherapy-induced nausea and vomiting (emesis). Varubi is approved in adults in combination with other drugs (antiemetic agents) that prevent nausea and vomiting associated with initial and repeat courses of vomit-inducing (emetogenic and highly emetogenic) cancer chemotherapy.

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Organized self-management support eases chronic depression

 

  • Randomized controlled trial including peer support helps patients at Group Health and Swedish Medical Center

 

Seattle, WA, USA (August 31, 2015) - How to reach people with chronic or recurrent depression? In a randomized trial, they benefited from a self-management support service that included regular outreach care management and a self-care group with a combined behavioral and recovery-oriented approach. Over 18 months, patients improved significantly in all four measured outcomes. Compared to patients in usual care, they had less severe symptoms and less likelihood of having major depression, higher recovery scores, and higher likelihood of being much improved. Psychiatric Services published Organized Self-Management Support Services for Chronic Depressive Symptoms: A Randomized Controlled Trial.

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New, rapid dementia screening tool rivals 'gold standard' clinical evaluations

 

  • Test takes 3-5 minutes to complete and can be used by a layperson

 

Boca Raton, FL, USA (August 12, 2015) - Determining whether or not an individual has dementia and to what degree is a long and laborious process that can take an experienced professional such as a clinician about four to five hours to administer, interpret and score the test results. A leading neuroscientist at Florida Atlantic University has developed a way for a layperson to do this in three to five minutes with results that are comparable to the "gold standard" dementia tests used by clinicians today.

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Better training tools recommended to support patients using adrenaline auto-injectors

  • Training device and audio-visual material expected to promote appropriate use of auto-injectors

London (June 26, 2015) - The European Medicines Agency (EMA) has recommended several measures, including the introduction of more effective educational material, to ensure that patients and carers use adrenaline auto-injectors successfully. Adrenaline auto-injectors are potentially life-saving treatments for anaphylaxis (severe allergic reactions) while the patient waits for emergency medical assistance.

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Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 22-25 June 2015

 

  • Ten new medicines, including two enzyme replacement therapies for rare diseases, recommended for approval

 

London, UK, (June 26, 2015) - Ten new medicines have been recommended for approval at the June 2015 meeting of the Committee for Medicinal Products for Human Use (CHMP).Two enzyme replacement therapies for the treatment of rare genetic diseases received a positive opinion from the CHMP: Kanuma (sebelipase alfa) for the treatment of lysosomal acid lipase deficiency, and Strensiq (asfotase alfa), the first therapy for the bone disease hypophosphatasia that started in childhood. For more information on these two enzyme replacement therapies, both of which have an orphan designation, please see the press releases in the grid below.

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New MUHC research warns DINCH plasticizer may need further safety evaluation

Is phthalate alternative really safe?

 

Montreal, Canada (June 17, 2015) - A commonly used plasticizer known as DINCH, which is found in products that come into close contact with humans, such as medical devices, children's toys and food packaging, might not be as safe as initially thought. According to a new study from the Research Institute of the McGill University Health Centre (RI-MUHC) in Montreal, DINCH exerts biological effects on metabolic processes in mammals. The findings, published in the journal Environmental Research, may have important implications since DINCH has been promoted by industry has as a safe alternative to phthalate plasticizers, despite there being no publicly available peer-reviewed data on its toxicology.

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One in 5 young VTE patients require psychotropic drugs within 5 years

 

  • Mental health problems requiring psychotropic medication are double that of healthy peers

 

Dubrovnik, Croatia (June 14, 2015) - EuroHeartCare is the official annual meeting of the Council on Cardiovascular Nursing and Allied Professions (CCNAP) of the European Society of Cardiology (ESC). The 2015 meeting is held 14 to 15 June in Dubrovnik, Croatia, in collaboration with the Croatian Association of Cardiology Nurses.

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Lack of evidence on how to care for hip fracture patients with dementia

 

Norwich, UK (June 14, 2015) - Medical guidance on how to care for elderly people with dementia following a hip fracture is 'sadly lacking' according to researchers at the University of East Anglia. Almost half of all people who suffer hip fractures also have dementia. But a Cochrane Review published today reveals there is no conclusive evidence on how to care for this particularly vulnerable group. The review, which was funded by the National Institute for Health Research (NIHR), highlights an urgent need for better research into what strategies improve post-operative care - both within hospital settings and in the community.

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Dose reduction strategy can substantially reduce high cost of TNF inhibitor therapy in RA

 

  • Good clinical response to TNFi maintained when dose reduced by one-third

 

Rome, Italy (13 June 2015) - The results of a study presented today at the European League Against Rheumatism Annual Congress (EULAR 2015) showed that, in rheumatoid arthritis (RA) patients, a good clinical response to maintenance treatment with a tumour necrosis factor inhibitor (TNFi) was maintained even when the dose was reduced by one-third.

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How to manage pain in the ER: Ask the patient

 

WASHINGTON, USA (June 12, 2015) - Simply asking the question, "Do you want more pain medication?" resulted in satisfactory pain control in 99 percent of emergency department patients participating in a study. The study of a new evidence-based protocol to treat acute, severe pain in emergency department patients was published online yesterday in Annals of Emergency Medicine ("Efficacy of an Acute Pain Titration Protocol Driven by Patient Response to a Simply Query: 'Do You Want More Pain Medication?'").

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New drug can clear all psoriasis symptoms

 

Manchester, UK, (June 10, 2015) - A University of Manchester led trial of a new psoriasis drug has resulted in 40 percent of people showing a complete clearance of psoriatic plaques after 12 weeks of treatment and over 90 percent showing improvement. The research tested 2,500 people with psoriasis. Half were given a new drug - ixekizumab - either once every two or four weeks. The other half were given a placebo or a widely used drug for psoriasis called etanercept. 

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Motivate and empower cancer patients to improve their sleep Patterns

Sleep duration and quality may impact cancer survival rate

 

DARIEN, IL, USA (June 10, 2015) - A new study suggests that pre-diagnostic short sleep duration and frequent snoring were associated with significantly poorer cancer-specific survival, particularly among women with breast cancer. Results show that stratified by cancer site, short sleep duration and frequent snoring were associated with significantly poorer breast cancer-specific survival.

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Heavy consequences of extreme obesity

Obese patients at high risk of post-surgery complications

 

Edmonton, Canada (June 10, 2015) -  Research from the University of Alberta's Faculty of Medicine & Dentistry is revealing the heavy surgical consequences of severe obesity. The study, published in the February edition of the Canadian Journal of Surgery, looked at the results of severely obese patients in need of emergency surgery. Of the patients studied, nearly half (40 per cent) needed to be admitted to an intensive care unit (ICU), and just under one in five (17 per cent) did not survive to be discharged home.

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Use of a mini filter prevents pollen inhalation and results in significantly fewer symptoms such as sneezing, watery eyes and drowsiness

Danish nasal filter more than halves symptoms of hay fever

 

Aarhus, Denmark (June 9, 2015) - Getting through the pollen season can now become easier for some of the approximately 500 million people worldwide who suffer from sneezing and a runny nose, watery eyes and drowsiness during the allergy season (seasonal allergic rhinitis).  This is indicated by a controlled trial carried out by researchers from Aarhus University. The trial, which took place over two days, included 65 people with grass pollen allergies who were not receiving any medical treatment at that time. They were either equipped with a nasal filter or a placebo device.

 

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Scripps Whittier Diabetes Institute research points to benefits of care teams focused on managing Diabetes:

Hospital stays longer, more costly with poorly controlled blood sugar

 

BOSTON, USA (June 8, 2015) - Diabetes patients with abnormal blood sugar levels had longer, more costly hospital stays than those with glucose levels in a healthy range, according to studies presented by Scripps Whittier Diabetes Institute researchers at the 75th Scientific Sessions of the American Diabetes Association (ADA), which ends June 9 in Boston.

 

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No scientific evidence that it protects against depression, pain or other benefits

Eating the placenta: trendy but no proven health benefits and unknown risks

 

  • Placenta doesn't prevent postpartum depression, ease pain, boost energy or aid lactation
  • Celebrities spike trend, but no studies show human benefits
  • Unknown risks to women and babies

 

CHICAGO, Ill., USA (June 4, 2015) - Celebrities such as Kourtney Kardashian blogged and raved about the benefits of their personal placenta 'vitamins' and spiked women's interest in the practice of consuming their placentas after childbirth. But a new Northwestern Medicine review of 10 current published research studies on placentophagy did not turn up any human or animal data to support the common claims that eating the placenta -- either raw, cooked or encapsulated -- offers protection against postpartum depression, reduces post-delivery pain, boosts energy, helps with lactation, promotes skin elasticity, enhances maternal bonding or replenishes iron in the body.

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Public access defibrillators are increasing survival but are not being used enough

 

Brussels, Belgium (June 1, 2015) - New research presented at this year's Euroanaesthesia shows that use of public access defibrillation on people suffering cardiac arrest is associated with a large increase in chances of survival. However, despite the great potential, publicly accessible Automated External Defibrillators (AEDs) are not being used enough, concludes research by Dr Marianne Agerskov and colleagues at Rigshospitalet, University of Copenhagen, Denmark.

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If properly implemented

The safe surgery checklist could save more lives worldwide than any other single known intervention

 

Brussels, Belgium (June 1, 2015) - New research presented at this year's Euroanaesthesia meeting in Berlin suggests that the WHO-approved safe surgery checklist is working well in both high-income and developing countries. The study is by Dr Janet Martin and Professor Davy Cheng, Centre for Medical Evidence, Decision Integrity & Clinical Impact (MEDICI), and Department of Anesthesia & Perioperative Medicine, University of Western Ontario, London, ON, Canada.

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Anaesthesiology

Article concludes no reason for laughing gas to be withdrawn from operating theaters

 

Brussels, Belgium (May 31, 2015) - A debate at this year's Euroanaesthesia meeting in Berlin will focus on whether laughing gas (nitrous oxide) should be banned from the operating room. The debate coincides with an article on the "Current place of nitrous oxide in clinical practice" published in the European Journal of Anaesthesiology, that concludes there is "no clinically relevant evidence for the withdrawal of nitrous oxide from the armamentarium of anaesthesia practice or procedural sedation." The article has been prepared by a special taskforce of the European Society of Anaesthesiology (ESA), which organises Euroanaesthesia.

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Anaesthesiology

Smokers and those exposed to passive smoke require more anesthetic and painkiller during operations

 

Brussels, Belgium (May 29, 2015) - Research published at this year's Euroanaesthesia meeting in Berlin (30 May-2 June) shows that both smokers and those exposed to passive smoke require more anaesthetic and painkillers to reach the same level of anaesthesia as non-smokers. The study is by Dr Erdogan Ozturk, Department of Anaesthesiology and Intensive Care, Bezmialem Vakif University, Istanbul, Turkey, and colleagues.

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High rates of MRSA transmission found between nursing home residents, healthcare workers

 

  • Study finds transmission rates high in daily activities previously considered low-risk

 

NEW YORK, USA (May 28, 2015) - Healthcare workers frequently contaminate their gloves and gowns during every day care of nursing homes residents with drug resistant Staphylococcus aureus or MRSA, according to a new study. The findings were published online today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America.

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First Guideline on Management of Patients with Diabetes and Chronic Kidney Disease (CKD)

 

London, UK (May 28, 2015) - Diabetes mellitus is becoming increasingly prevalent and is considered a rapidly growing concern for healthcare systems. According to the WHO [1] there are currently more than 60 million patients with diabetes in Europe – and patients with diabetes are particularly at risk of developing chronic kidney disease. According to the latest annual report of the ERA-EDTA registry [2], 22.1% of all new dialysis patients are classified with diabetic nephropathy. Therefore it is to be feared that the global increase of diabetes will result in a higher prevalence of chronic kidney disease, too.

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Hip fractures in the elderly caused by falls, not osteoporosis

 

Helsinki, Finland, (May 27, 2015) - Anti-osteoporotic medication is not an effective means for preventing hip fractures among the elderly, concludes a study recently published in the BMJ. Proximal femoral fractures (i.e., hip fractures) occur in the world at a rate of 1.5 million per year, or 7,000 per year in Finland. As most such fractures occur among older people, their number is expected to grow as the population ages. Hip fractures often lead to permanently reduced mobility, quality of life and general health, as well as result in significant social costs.

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Survival Rate of Dialysis Patients Has Improved

 

London, UK (May 27, 2015) - At least 70 million Europeans suffer from chronic kidney disease (CKD). However, dialysis patients represent only 1 to 2% of the CKD population. CKD is clearly a disease that progresses slowly, but steadily – yet even in its early stages, CKD causes a dramatic increase in general and cardiovascular mortality. The sad truth is that many CKD patients die before reaching end-stage renal disease (ESRD), when they are dependent on renal replacement therapy (dialysis, transplantation). Risk calculations indicate that CKD is a negative cardiovascular prognostic factor as such, irrespective of the traditional mortality risks such as cholesterol or blood pressure. Five years ago, a systematic analysis published in the renowned journal, ‘The Lancet’ [1], involving more than 1.2 million patients, showed that total as well as cardiovascular mortality can be well estimated using simple kidney function tests.

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Chronic Kidney Disease: a Challenge for European Healthcare Systems

 

London, UK, (May 26, 2015) - 10% of the population is affected by chronic kidney disease (CKD). About 70 million Europeans have lost some of their kidney function and are at high risk of becoming dependent on renal replacement therapies (dialysis or transplantation). This is due, on the one hand, to demographic trends – people are becoming older, and loss of renal function is a symptom of old age. Yet demographic trends alone do not explain the steep upward trend in chronic kidney disease (CKD). Several other conditions are linked to increased incidence of CKD, e.g. diabetes mellitus, hypertension, smoking, ageing, and obesity. All subjects having these characteristics should not only be adequately treated for their primary condition, but should also be regularly screened and treated specifically for their kidney disease.

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Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 18-21 May 2015

 

  • Eight new medicines, including three cancer immunotherapies, recommended for approval

 

London, UK (May 22, 2015) - The Committee has recommended granting a marketing authorisation for Repatha (evolocumab), a first-in-class treatment to lower high levels of cholesterol in the blood of people who are unable to control their cholesterol despite taking optimal doses of statins or who cannot take statins. Repatha is also recommended to treat homozygous familial hypercholesterolaemia, a rare inherited disorder. Repatha is the first monoclonal antibody in this therapeutic area and provides a new treatment option for patients who are unable to control their high cholesterol despite taking currently available therapies. For more information on Repatha, please see the press release in the grid below.

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Patient risk model can help target costly HCV treatment to those with most urgent Need

Helping doctors predict what's next for patients diagnosed with Hepatitis C

 

ANN ARBOR, Mich., USA (May 21, 2015) - A team of researchers at the University of Michigan Health System has developed a risk prediction model that helps identify which hepatitis C patients have the most urgent need for new anti-viral drugs. Rallying baby boomers to be screened for hepatitis C took off as effective treatments emerged to wipe out the liver-damaging virus. But high costs that can rise to more than $80,000 for a round of treatment have complicated the promise of providing curative treatment for the estimated 3.2 million people in the United States with hepatitis C.

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Chinese herbal mixture significantly reduces fatigue in cancer patients

 

Rochelle, NY, USA (May 20, 2015) - Cancer patients suffering from moderate to severe fatigue reported significantly less fatigue within 2-3 weeks of treatment with the traditional Chinese medicine herbal mixture Ren Shen Yangrong Tang (RSYRT), a soup containing 12 herbs. The safety and efficacy of RSYRT in this Phase I/II trial are presented in an article in the Journal of Alternative and Complementary Medicine, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Alternative and Complementary Medicine website until June 20, 2015.

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